The word on the block is that NMN and resveratrol are a match made in heaven that can have you aging like fine wine. Is it true? Well, existing research suggests that the two go together like Bonnie and Clyde, capable of annihilating enemies that can make you age faster and hinder you from living a happy and fulfilling life.
Wondering why this winning combination is so gosh darn good together? Here’s a scientific breakdown of their powerful partnership.
How NMN and resveratrol help you age smarter
We’ll get to all the nitty gritty details about NMN and resveratrol’s combined benefits in just a sec. But let’s start by dropping a few facts about resveratrol. This powerful antioxidant is capable of attacking threats to the body that could surface later in life, like heart disease and cancer. If you’re a regular consumer of red wine, berries, or peanuts—congratulations! There’s resveratrol in all three of these sweet sensations, and you’re probably already enjoying its benefits unaware.
Paired with NMN, resveratrol’s propensity to put out internal fires is even fiercer. Studies say that this dynamic duo can accomplish a long list of health benefits when combined—showcasing positive effects on your cardiovascular, metabolic, and brain health, among other areas of the body. A 2022 study further highlights this synergy—beyond simply boosting NAD levels, combining NMN with resveratrol enhances the distribution of NMN and its metabolite NR. This makes the combination more effective than NMN alone, particularly for heart-lung health.
Their biggest victory? Awakening the longevity genes in your body that are meant to help you live longer, and breathe life into the cells to get more energy out of them. This helps the body feel more invigorated and less like a snooze fest. NMN and resveratrol are also vicious partners in crime when warring against diseases that could surface with age, like diabetes and Alzheimer’s disease.
“Chronic inflammation is a significant contributor to aging and age-related diseases,” says Luis Cifuentes, Wonderfeel’s Director of R&D and Product Development. He continued on to say that “resveratrol has powerful anti-inflammatory properties that help reduce the production of pro-inflammatory molecules,” and that “NMN also plays a role in modulating inflammation through its impact on NAD levels, which are involved in controlling immune responses.”
Anti-aging: the shared benefit
So what’s the deal with NMN and resveratrol when it comes to aging? Just ask anti-aging expert and Harvard professor David Sinclair—he likens NMN to the fuel and resveratrol to the oil needed to keep the body running smoothly. In other words, you need both to keep the engine of longevity humming along.
But what makes them such a powerful duo? The key lies in two major players—sirtuins and CD38. Sirtuins, often referred to as longevity genes, depend on NAD to regulate cellular repair and stress resistance. Meanwhile, CD38, an enzyme that has been gaining significant attention in aging research, acts as a slow leak in your longevity tank. As we age, CD38 levels naturally rise, becoming the biggest consumer of NAD in the body. The more CD38 you have, the faster your NAD levels decline.
That’s why the best approach isn’t just increasing NAD but also slowing down its biggest drain. While NMN keeps the fire burning by supplying that NAD in abundance, resveratrol is necessary for igniting the body’s sirtuins and slowing down the activity of CD38. In essence, NMN and resveratrol aren’t just working together to fuel longevity genes—they’re also plugging the leak that speeds up aging.
In their own individual ways, both NMN and resveratrol can greatly influence the body’s mitochondrial function as well. This could help make or break the aging process depending on its strength level. A weakened mitochondrial function could cause a major blow to your organs, muscles, energy, and more. On the bright side, NMN and resveratrol can influence the body to create less oxidative stress, which is the key to sustaining a stronger mitochondrial function in the long run.
What the science says
The way the research checks out, it’s safe to say that NMN and resveratrol are quite stellar for your health and have the potential to add more wonderful and fulfilling years to your life. How do we know? Multiple scientific studies show that all the signs are there.
Cellular & DNA saviors
When your DNA experiences a few hiccups from time to time, NMN steps in to help fix what’s broken, and many studies have demonstrated this. NMN can also cause aging cells to liven up a bit more, according to research. This is fantastic for your body in the long run, helping cells stay strong and active as you age. And of course, it’s already been established that resveratrol stands up to oxidative stress in defense of your cells, a major threat to aging healthfully.
Strong brain, clear mind
As it turns out, NMN and resveratrol can clear the fog in your noggin that might be affecting your concentration. They make a great team in extinguishing cognitive decline, which affects the brain’s ability to think clearly. Many researchers have put this theory to the test and have come back with promising results.
In one study, participants recovering from a traumatic brain injury saw significant improvements in their cognitive function after taking resveratrol. Another study witnessed a change in mice dealing with cognitive decline after taking an NMN and resveratrol supplement. In the end, the mice were left with a clearer conscience.
Heart healthy
Resveratrol’s “mama bear” instincts with the cardiovascular system—you know, the one that keeps your heart beating—are becoming more and more apparent with developing research. Its protective effects on the cardiovascular system have a lot to do with its antioxidant and anti-inflammatory properties, which help maintain healthy blood flow and reduce oxidative stress on the heart.
But the real magic happens when NMN and resveratrol team up. Murine studies show that this combo supercharged NAD levels—boosting them by 1.6 times in the heart and 1.7 times in muscle tissue compared to NMN alone. By boosting NAD levels in the heart and muscles, NMN and resveratrol work together to support cardiovascular health, fuel energy metabolism, and help keep these tissues strong as we age.
Turning back the clock on skin & hair
With resveratrol’s natural inclination to heal wounds and NMN’s general anti-aging effects on the body by boosting your NAD levels, proven in past research, both can have equally positive effects on your skin.
But their benefits don’t stop at just glowing skin—new researchfound that NMN, resveratrol, and EGCG (a fancy name for something in green tea) can calm down an enzyme called GSK-3 that affects how your hair grows. By keeping GSK-3 in check, these compounds may help support healthy hair growth, strengthen follicles, and even play a role in preventing hair loss.
What’s the recommended dose for NMN and resveratrol supplements?
Now, let’s talk about dosages. Finding the sweet spot for the powerful NMN and resveratrol combination is key.
- NMN: The typical NMN dosage range hovers between 250mg to 1,000mg per day. While early studies often used lower doses, experts increasingly recommend higher doses (600-1,200mg) for optimal benefits. Renowned longevity researcher Dr. David Sinclair, for example, has publicly shared that his daily regimen includes 1,000mg of NMN. Similarly, Dr. Eric Verdin, the president of the Buck Institute for Research on Aging, also takes 1,000mg daily and recommends higher doses for optimal effects.
- Resveratrol: Now, here’s where things get interesting with resveratrol. While some may be tempted to chase high doses, studies show that a lighter dose of resveratrol causes it to act as an anti-apoptotic agent, simply meaning that it can prevent cells from experiencing an early death. Wonderfeel’s formulation utilizes a carefully considered dose within the recommended range of 100-500mg per day. This approach aligns with emerging research suggesting that smaller doses may offer greater efficacy for certain benefits, such as supporting heart health, improving blood vessel function, and promoting cellular protection. Plus, it helps minimize the risk of any potential side effects.
Are there any side effects of NMN & resveratrol supplementation?
As of now, there are no publicly expressed side effects of taking NMN and resveratrol. However, we know that too much of anything isn’t good. Go overboard on any supplement, and you’re likely to experience minor side effects, whether that’s headaches, nausea, or vomiting. Cifuentes confirmed this by sharing that “minor effects due to discomfort in the gastrointestinal tract have been reported, particularly in higher doses than we recommend.”
The longevity equation: what’s missing?
NMN and resveratrol make a great team—but they’re only part of the story. CD38, the enzyme that ramps up with age, is the real troublemaker, breaking down NAD faster than your body can replenish it. And what fuels this NAD drain? Chronic inflammation.
Resveratrol activates apigenin within cells to slow CD38 while enhancing sirtuin activation. But even with resveratrol’s help, CD38 keeps chipping away at your NAD supply. That’s where Wonderfeel’s formula takes things further.Hydroxytyrosol, a potent antioxidant from olives, helps reduce CD38 production at the source, while ergothioneine shields your cells from oxidative stress—because less damage means less NAD wasted on repairs.
By combining NMN to fuel NAD, resveratrol to activate longevity genes, hydroxytyrosol to regulate CD38, and ergothioneine to protect your cells, Wonderfeel Youngr™ NMN doesn’t just boost NAD—it helps you hold onto it longer, right where your body needs it most.