Becoming a parent is one of the most treasured life milestones known to humankind, but the childbearing process can be a challenge for individuals who face fertility issues. As men and women age, the decline in NAD becomes more pronounced, leading to a decline in fertility. This is why adults in their prime have a significantly lower chance of becoming pregnant compared to younger women with higher fertility rates. Then again, there’s hope, as NMN supplementation can replenish the body’s NAD levels.
Conception later in life more likely with NMN?
Animal studies created the foundation for the theory that NMN supplementation can improve age-related fertility issues by replenishing the body’s NAD levels, causing improvements in egg production and ovarian function in women as well as sperm quality and motility (or movement) in men. Further human clinical studies will be necessary to validate these findings, and we will then be able to more broadly evaluate the effects of NMN on both male and female fertility.
A 2020 study evaluated the effects of NMN supplementation on aging mice. NMN raised their NAD levels, as suspected, leading to greater reproductive function. A variety of fertility testing indicators provided proof, including whether late-stage NMN treatment could enhance oocyte (or premature egg) development. One aspect of the study involved treating 12-month-old female mice—for four weeks—with NMN in drinking water. Female mice start experiencing declining fertility around eight months of age. Ultimately, NAD levels increased in the aged mice’s oocytes (or premature eggs), enhancing the egg quality.
This revealed NMN’s potentially positive effects on fertilization and implantation, which results in conception after a fertilized egg successfully attaches itself to the lining of the uterus. As NMN improves egg quality, immature eggs are more likely to reach the fertilization stage, resulting in healthy pregnancies.
A different 2022 animal-based clinical study assessed how NMN supplementation affected male fertility in diabetic mice. It also had positive influences on male fertility, which NAD levels also impact by improving sperm quality and motility.
The science behind NMN’s influence on reproductive health
As the years progress, our bodies produce less NAD. Not only that but low NAD levels are coincidentally linked to developing a compromised mitochondrial function. We can’t procreate without mitochondria, as it’s the powerhouse of cells, and they supply the energy required for oocyte maturation, fertilization, and embryonic development. This only means one thing—a compromised mitochondrial function is a fertility recipe for disaster.
It doesn’t just inhibit female fertility, either. Sperm mitochondria, in particular, are largely responsible for providing the energy for sperm motility in males. Inconsistencies in sperm motility can subsequently hinder male fertility. Fortunately, the supplementation of NMN can ultimately reverse this effect by enhancing mitochondrial function with replenished NAD levels.
Multiple fertility-related benefits of NMN supplementation in aged mammals explain why NMN has such high potential as a natural fertility solution.
How else can NMN supplements impact fertility?
NMN has received growing attention for its positive influences on fertility for both men and women. But supposedly, NMN doesn’t just help improve egg quality, sperm quality, ovarian function, and mitochondrial function, it boosts reproductive function in other ways, like improving DNA integrity with its NAD replenishing properties—which is also crucial for decreasing the likelihood of developmental congenital disabilities and genetic disorders.
Because genetic alterations can be passed down from generation to generation, DNA damage can be harmful. The body needs sufficient NAD to correct or prevent cell damage and genetic mutations, but declining NAD levels can counteract this and halt DNA repair. NMN positively impacts DNA repair by enhancing restorative mechanisms that could preserve the original genetic material within the eggs.
Additionally, the story mentioned earlier notes that NMN is a strong defense against oxidative stress, which occurs when harmful free radical production in the body produces an imbalance between the body’s free radical neutralization abilities. Expected consequences of the imbalance are egg damage and fertility, sperm, and reproductive organ issues. The benefit of NMN, in this scenario, is that supplementation can strengthen the body’s ability to protect itself against oxidative stress, leading to enhanced protection from reproductive cell harm.
Consistent hormone levels, like estrogen and progesterone, can help create a healthy environment for regular menstrual cycles and ovulation. The influence of NMN on various hormones has been the subject of clinical trials, but the results have yet to be published, so we look forward to seeing them should they ever be made available.
The good news is…
For those choosing to postpone parenthood, we’ve opened a whole new “window of opportunity” through science, and the wonderful part is that adults in their prime now have more options to enhance their reproductive potential than ever before.
We’re seeing overall positive results related to reproductive health when we look at research assessing NMN’s effects on fertility. There’s not only evidence of NMN improving egg and sperm quality, but it’s also shown to reverse declining age-related effects on fertility, like restoration of NAD levels.
More human-based research is warranted to better grasp its mechanisms, safety, and effectiveness on human fertility. As research continues to expand, it’s clear that NMN supplements for fertility, as well as for general use, are poised to become one of the top natural fertility treatments out there.
So, if you’re looking for something to help keep you healthy into your prime years, Wonderfeel’s Youngr™ NMN is the way to go, as we’ve designed our patented formula to delay biological aging at the cellular level. There is also the option of pure NMN Capsuls™ for those who prefer single-ingredient supplements. Either way, you can be assured you are getting a science-backed and physician-approved supplement to boost your body’s NAD levels.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.