Key Takeaways
- Amazon removed NMN supplements following an FDA letter that retroactively revoked NMN’s status as a dietary supplement, citing ongoing pharmaceutical development—not safety concerns—as the reason.
- The ban ended up removing many low-quality, unregulated NMN products—particularly those from questionable overseas manufacturers—which may ultimately improve consumer safety and product standards.
- Consumers can still access high-quality NMN supplements through trusted brands like Wonderfeel, which use clinically tested, GMP-certified formulations and are committed to science-backed wellness.
- The FDA’s decision was controversial, especially since it prioritizes pharmaceutical interests over consumers’ access to safe and effective supplements.
- Wonderfeel remains committed to keeping NMN accessible outside of Amazon.
In September 2025, the FDA officially reversed its 2022 stance and confirmed that NMN is lawful for use in dietary supplements. Amazon first pulled NMN after the FDA’s reversal letter in 2022, but with this clarification, the cloud of uncertainty has lifted — restoring consumer confidence and opening the door for retailers to bring NMN back.
What happened?
On February 16th, Amazon sent a message to all NMN companies on its platform. Their letter states, “Products that contain NMN as an ingredient can no longer be sold or distributed as a dietary supplement by manufacturers or retailers in the United States.” This means that Amazon has effectively banned NMN from its website in March 2023.
Fast-forward to September 2025, and the FDA has clarified that NMN is lawful as a dietary supplement. In other words, consumers can once again shop with confidence, and retailers have the green light to stock NMN products. Trustworthy brands like Wonderfeel Biosciences never wavered, continuing to provide high-quality, clinically tested NMN through this entire period of uncertainty.
What does the Amazon ban on NMN mean to consumers?
Back in March 2023, consumers could no longer buy NMN products on Amazon, which caused major inconvenience. Today, with the FDA’s clarification, retailers once again have the option to reintroduce NMN products to their shelves.
According to some industry watchdogs, there was a silver lining to Amazon’s 2023 ban. It temporarily cleared the marketplace of many questionable, low-quality NMN products — particularly those from overseas manufacturers with questionable purity standarts. By cutting off their main U.S. sales channel, Amazon inadvertently protected consumers from potentially unsafe products.
Did Amazon ban NMN due to a safety issue?
No, Amazon’s banning of NMN sales wasn’t related to safety concerns. On November 4, 2022, the FDA issued a controversial letter revoking NMN’s previously assigned status as a dietary supplement and excluding it from the definition. The reason behind this decision was the ongoing investigation of NMN as a potential pharmaceutical drug. As a result, Amazon decided to remove the sale of NMN products from its platform.
While Amazon’s decision to remove NMN products was unrelated to safety issues, it is worth considering that safety concerns have arisen in the past. Primarily are reports of phony NMN supplements sold mostly on Amazon with inadequate purity levels, no stability studies, and without GMP certification. However, we encourage consumers to remain positive and continue incorporating NMN supplements into their daily health and wellness routine, provided they source them from reputable and trusted sources.
How and where to buy safe NMN products after Amazon’s removal?
Even during the Amazon ban, folks could still find NMN directly from established brands, such as Wonderfeel Biosciences, which possess a deep understanding of NAD precursors and back their supplements with clinical research. These sources are trustworthy, and consumers can rely on them to provide safe and effective NMN products manufactured in GMP-certified facilities. With the FDA’s clarification, access will only continue to expand.
Why did Amazon ban sales of NMN products at its store?
Amazon banned sales of NMN products in its stores after the FDA’s November 2022 letter stated that NMN was not considered a dietary supplement. Their stated reason is to protect a pharmaceutical drug development application for a patented version of NMN. It’s disheartening that Amazon is putting the interests of the pharmaceutical industry ahead of the health and well-being of its customers who rely on NMN supplements in their daily regimen.
More on the FDA’s Decision
The FDA’s announcement triggered backlash from the wellness and supplement communities. Wonderfeel has been actively consulted legal experts to navigate this evolving situation while ensuring product availability for subscribers and new customers.
Know that our commitment to making a product you’ve come to rely on is unwavering. This is a perfect time to emphasize that safety, science, innovation, and a proactive approach to wellness are at our core.
Our guiding principles
- We take all measures to ensure that our customers receive a safe and stable supplement, tested for purity by accredited third-party labs. We produce our product at facilities in the USA certified for Good Manufacturing Practice (cGMP).
- The NMN sourced for our products is clinically tested in one of the most extensive human clinical trials to date. Based on various health markers, the resulting toxicology report shows that NMN at 900mg per day is well-tolerated.
- We continue to advance the science of NMN. On November 10, we announced an in vitro study of our novel NMN supplement on human cells.
- We believe in an individual’s right to govern their own wellness protocols. We will make our NMN products available outside of the Amazon ban in jurisdictions that protect the rights of consumers above pharmaceutical companies. We will continue sales of NMN as a dietary supplement.
- Countries like Japan have sold NMN as a dietary supplement since 2016. It’s worth noting that this was well before Metro International Biotech LLC, the company mentioned in the FDA’s statement, began conducting research on their NMN derivative in the United States.
A world where everyone wins
- As part of our current preclinical and clinical studies, we are laying the groundwork for Pharma development of our formulations. These can run parallel to our nutraceutical pursuits without infringing on anyone else’s IP or the ability to market our products as dietary supplements. While we advocate for the protection of drug development, we believe that such efforts shouldn’t deprive the public of safe and readily used supplements. We firmly believe that there exist many sustainable business models for the pharmaceutical drug development of NMN and its over-the-counter derivatives.
- In keeping with our founding principle–a proactive approach to health and wellness–we commit to providing publicly available, natural solutions backed by rigorous science. We have observed tens of thousands of Americans safely benefiting from NMN supplements.
Additional expert perspective
Robert (“Bob”) Durkin, former deputy director of dietary supplements at the FDA (2015–2019), has highlighted the unusual nature of the FDA’s position on NMN. He said, “It’s hard to imagine that’s what Congress intended” when referring to the agency’s retroactive exclusion of NMN from the definition of a dietary supplement after it was already legally on the market. This underscores the regulatory confusion that surrounded NMN during this period while reinforcing that this dispute was about classification, not consumer safety or product efficacy.
A 2025 update: NMN, FDA, and what it means for you
What’s the latest on NMN’s regulatory status?
A lot has happened since the FDA’s 2022 letter. In September 2025, the FDA officially reversed course, clarifying that NMN is indeed lawful for use in dietary supplements. This marks the end of three long years of confusion, legal back-and-forth, and general marketplace disruption.
Despite confusion in the headlines, NMN is now clearly accessible and lawful in the U.S. The debate has been resolved: this was always a classification issue, not a safety concern. And again, the debate was a regulatory dispute about classification—not about safety.
Initially, the FDA allowed NMN sales under a New Dietary Ingredient Notification in 2022 but later reversed its stance, arguing NMN could not be sold as a dietary supplement due to pharmaceutical investigations. This led Amazon to remove NMN products in 2023. However, research continues to support NMN’s safety and benefits for cellular energy and healthy aging. And now, the FDA has officially reversed course.
The legal challenge and what it means for you
In response to the FDA’s decision, the Natural Products Association (NPA) filed a lawsuit and citizen petition, challenging the FDA’s interpretation and seeking to maintain NMN’s availability as a supplement. In November 2024, a court granted a joint motion to stay the case, preventing the FDA from enforcing actions against NMN products during this period. The September 2025 reversal brings much-needed clarity:
- NMN is lawful again: You can purchase NMN in the U.S. with full regulatory clarity.
- Access is expanding: Retailers and marketplaces that once pulled NMN (like Amazon) now have the green light to bring it back.
- Safety was never the issue: NMN remains backed by clinical data and a strong safety profile.
The bottom line
NMN supplements are now confirmed to be legal, accessible, and safe. With the FDA’s September 2025 clarification, there’s no longer any uncertainty—NMN is officially recognized as a lawful dietary supplement in the U.S. your ability to use NMN as part of a proactive wellness routine is secure. Wonderfeel will continue to advocate for your right to choose high-quality supplements while advancing the science of NMN for healthy aging.
Frequently Asked Questions
Will Amazon start selling NMN again now that the FDA has clarified its status?
It’s a safe bet. Amazon removed NMN from its platform in 2023 after the FDA’s reversal letter created regulatory uncertainty. With the FDA’s 2025 clarification confirming NMN is lawful as a dietary supplement, major marketplaces now have the green light to bring NMN products back. It may take some time for Amazon and others to update their policies, but this decision opens the door for NMN’s return to these mainstream channels.
Why did the FDA ban NMN?
In November 2022, the FDA revoked NMN’s status as a dietary supplement under the “drug preclusion rule,” citing its investigation as a potential pharmaceutical drug. This decision wasn’t about safety—NMN has consistently demonstrated a strong safety profile. It was a regulatory thing. In September 2025, however, the FDA officially reversed course and clarified that NMN is lawful for use in dietary supplements.
Why was NMN removed from Amazon?
Amazon removed NMN because the FDA revoked its status as a dietary supplement, citing its ongoing investigation as a potential pharmaceutical drug. In response, Amazon chose to remove all NMN products from its platform to comply with this regulatory change—even though the decision wasn’t based on safety concerns.
Is NMN banned or just restricted by the FDA?
No. As of September 2025, NMN is legal for use in dietary supplements. The earlier dispute began with the FDA’s 2022 letter but has happily been resolved.
Does the NMN FDA announcement mean it’s unsafe?
No, the FDA’s action against NMN doesn’t mean it’s unsafe. The restriction was based on its investigation as a potential pharmaceutical drug—not due to any reported safety issues. In fact, high-quality NMN supplements have shown good safety profiles in clinical studies.
Can I still buy NMN after the FDA’s announcement?
Reputable brands like Wonderfeel have never stopped making it directly available.
