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Your Guide to High-Performance and Pure NMN Supplements

Andrew Salzman MD

Medically reviewed by Andrew Salzman MDAndrew Salzman is a professor, physician, inventor, and biomedical entrepreneur with over 30 years of experience in drug discovery and development.

Written by Patricia Ryan
With NMN supplements flooding the market, ensuring purity is essential. It’s vital to verify the source and reputation of the brand. Ensure your NMN has test results from an accredited third-party lab and is manufactured in facilities with top-notch cGMP standards. At Wonderfeel, we guarantee our NMN is pure, thanks to our rigorous certifications and transparent testing practices. Only then can you count on NMN's full range of benefits!

Ah yes, the age-old question: How can I trust that a supplement contains what the label claims? There are an increasing number of companies selling NMN supplements with a generic name and no other online presence. Unfortunately, many of these newcomers are selling inferior products, luring consumers with claims of “99% pure NMN” or “advanced liposomal technology.”

These enticing labels can be misleading, promising more than they deliver. As the interest in longevity and wellness supplements grows, so does the potential for disappointment. It is important for you to know that you are getting a high-quality NMN supplement that delivers the expected results. We will discuss how to do just that.

What is pure NMN, and why does it matter?

When it comes to NMN supplements, purity is paramount. Contaminants in NMN can dilute its effectiveness and potentially lead to unforeseen health concerns. Choosing a pure NMN supplement maximizes the outcome to ensure you’re getting its intended benefits. However, the question remains, how can you tell if your NMN is truly pure, and does 99% pure NMN always equate to high quality?

While NMN purity is important, it’s not the whole story. In order to establish pure NMN, it is critical to inspect the product for things like toxins, yeast, and mold. These unwanted substances may find their way into supplements during production when manufacturers aren’t cGMP compliant. In some cases, the presence of even trace amounts of certain impurities can be harmful. Unfortunately, some brands sidestep these tests altogether, leaving consumers at risk.

Quality differences between GMP (Good Manufacturing Practice) and cGMP (Current Good Manufacturing Practice)
Cost differences between GMP (Good Manufacturing Practice) and cGMP (Current Good Manufacturing Practice)

Guaranteeing high standards of purity and quality

While pure NMN is essential, it’s not the only factor that contributes to a high-performance supplement. There are also a few other considerations you need to take into account.

Understanding cGMP: High-quality supplement manufacturing

cGMP, or Current Good Manufacturing Practices, is a set of FDA regulations that ensure every product hits the highest marks for quality, purity, and effectiveness. These guidelines require manufacturers to implement robust quality control, utilize high-quality raw materials, and adhere to strict manufacturing processes. The “C” in cGMP stands for “current,” highlighting the need for manufacturers to use up-to-date technologies and methods. 

cGMP NMN supplement purity badge

Let’s talk COA’s. 

Ever wonder what happens behind the scenes when it comes to NMN supplement quality? The answer lies in a document called a Certificate of Analysis, better known as a COA. It’s a crucial document that validates the potency of NMN, but it doesn’t stop there. Reputable manufacturers, like Wonderfeel, send their finished products to an unbiased third-party lab for testing before they ever reach the consumer. 

These specialized labs will test for harmful substances like arsenic, cadmium, lead, mercury, and microbial contaminants such as yeast & mold, E. coli and a host other bacteria. Consider a COA as a report card for your NMN supplement, ensuring its quality, purity, potency, and safety through independent lab testing. But it’s only as valuable as the lab that issued it. Here’s how to ensure the COA holds weight:

  • Lab Accreditation: A COA’s credibility hinges on the lab that issued it. Look for a COA from a lab with accreditation by a reputable organization. This tells you the lab follows strict testing standards, ensuring the results of your NMN supplement’s COA are accurate.
  • QR Code Verification: COAs issued by accredited labs are often enhanced with QR codes; all Wonderfeel certificates include these codes. Scan the code with your smartphone to see the actual report on the lab’s website. This transparency allows you to verify the information firsthand. If the product you are investigating lacks a QR code on its COA, proceed cautiously, as this may be a red flag regarding purity.

Interpreting your COA: Understanding safety levels

COAs may demonstrate that hazardous materials have been tested and display acceptable values, but how do you know these values are safe for consumption?

Here’s where understanding regulatory guidelines comes into play:

  • FDA Standards: The Food and Drug Administration (FDA) sets limits for acceptable impurity levels in supplements. These limits are set to ensure consumer safety and give you peace of mind.
  • California Prop 65: Going a Step Further: California has more stringent regulations for certain impurities, known as Prop 65. Think of it as an extra layer of protection. 

At Wonderfeel, your safety is our top priority. That’s why all our NMN supplements meet not just the FDA requirements but also the tighter rules set by California’s Prop 65. Our Certificates of Analysis (COAs) provide detailed information about the purity and potency of our products. Third-party laboratories generate these reports, ensuring transparency and independent verification of quality.

A lab setup with glassware, a microscope, and a computer showing NMN's molecular structure

Ingredient quality: 

Beyond NMN purity, consider the quality of other ingredients used in the capsules. Look for brands that prioritize clean formulas free from harmful fillers or additives.

Brand transparency: 

Choosing an NMN supplement is a personal decision, and understanding what’s behind the label is crucial. Look for brands that prioritize transparency by readily providing information on sourcing, manufacturing processes, and lab testing results.

The label of a high-quality NMN supplement will provide clear information that makes your decision about its use simple. Here’s what to look for on the label:

  • Manufacturer Information: Knowing the name, address, and website of the manufacturer allows you to contact them directly with any questions or concerns.
  • Ingredients: Make sure the label lists all active and inactive ingredients so you can identify allergens or choose a formula compatible with your dietary restrictions.
  • Quantity and Dosage: The quantity of NMN per serving and recommended daily dosage should be clearly stated.
  • Lot Number and Expiry Date: These details help track product batches and ensure you’re consuming the supplement within its optimal potency timeframe.
  • Storage Instructions: Proper storage is essential for maintaining NMN’s effectiveness. The label should provide guidance on storage temperature and light exposure.
  • Warnings and Contraindications: The label should list any potential warnings or contraindications for using the NMN supplement. This helps you determine if it’s safe to use based on your health profile.

Reputable NMN manufacturers prioritize transparency in brand information and product labeling so you can make informed health decisions.

Understanding liposomal NMN and its impact on purity

Liposomal technology, often cited for its ability to enhance the bioavailability of NMN supplements, encapsulates nutrients within tiny lipid-based vesicles. However, this method also raises significant concerns about the purity and stability of NMN.

Liposomes are microscopic spheres made of fats that can potentially improve a supplement’s uptake. However, there’s a catch – these tiny transporters can be a bit delicate. Over time, they might break down or leak their contents. Two concerns arise as a result of this instability:

  • Purity Potential: If the liposomes break down, it could introduce unwanted impurities into the NMN.
  • Dosage Dilemma: Leaking liposomes might also mean that you’re not getting the full dose of NMN as advertised. This could affect how well it works.
A yellow lipid-based liposome sphere used in NMN supplements
A yellow liposome breaking apart, showing leakage concerns
A yellow liposome with contents leaking out, illustrating instability

Currently, there is no solid research to definitively say whether liposomal NMN is truly more effective or safe than traditional forms. Without substantial evidence from well-conducted studies, liposomal NMN may not be the best choice for improved bioavailability.

In the absence of substantial evidence from well-conducted studies, we shouldn’t rely on liposomal NMN for improved bioavailability.

Beyond purity and quality: Key factors for a high-performance NMN experience

At the heart of our production process are Current Good Manufacturing Practices (cGMP) rules and requirements. Wonderfeel is produced in the USA at cGMP-certified facilities which are held to the most strict FDA regulations. Always committed to transparency, we provide trackable, 3rd party lab results for every product we make. But that’s not all. 

Youngr™ is activated by incorporating a powerful synergy of ingredients like ergothioneine, resveratrol, hydroxytyrosol, and Vitamin D3, all known for their antioxidant and sirtuin-activating properties. This comprehensive approach ensures a well-rounded supplement that prioritizes your well-being. Trust Wonderfeel to deliver superior quality and achieve greater results.

What about the overall safety of NMN?

Aside from purity, if you are concerned about the overall safety of NMN as a supplement, look no further. We have a quick article about that too!

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